Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial
Identifieur interne : 000311 ( Main/Exploration ); précédent : 000310; suivant : 000312Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial
Auteurs : Santosh S. Martande [Inde] ; Minal Kumari [Inde] ; A. R. Pradeep [Inde] ; Sonender Pal Singh [Inde] ; Deepak Kumar Suke [Inde]Source :
- Journal of Dental Research, Dental Clinics, Dental Prospects [ 2008-210X ] ; 2017.
Abstract
Url:
DOI: 10.15171/joddd.2017.004
PubMed: 28413591
PubMed Central: 5390121
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial</title><author><name sortKey="S Martande, Santosh" sort="S Martande, Santosh" uniqKey="S Martande S" first="Santosh" last="S. Martande">Santosh S. Martande</name><affiliation wicri:level="1"><nlm:aff id="A01">Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune</wicri:regionArea><wicri:noRegion>Pune</wicri:noRegion></affiliation></author><author><name sortKey="Kumari, Minal" sort="Kumari, Minal" uniqKey="Kumari M" first="Minal" last="Kumari">Minal Kumari</name><affiliation wicri:level="1"><nlm:aff id="A02">Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Pradeep, A R" sort="Pradeep, A R" uniqKey="Pradeep A" first="A. R." last="Pradeep">A. R. Pradeep</name><affiliation wicri:level="1"><nlm:aff id="A03">Department of Periodontics, Government Dental College & Research Institute, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Government Dental College & Research Institute, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Pal Singh, Sonender" sort="Pal Singh, Sonender" uniqKey="Pal Singh S" first="Sonender" last="Pal Singh">Sonender Pal Singh</name><affiliation wicri:level="1"><nlm:aff id="A03">Department of Periodontics, Government Dental College & Research Institute, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Government Dental College & Research Institute, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Kumar Suke, Deepak" sort="Kumar Suke, Deepak" uniqKey="Kumar Suke D" first="Deepak" last="Kumar Suke">Deepak Kumar Suke</name><affiliation wicri:level="1"><nlm:aff id="A03">Department of Periodontics, Government Dental College & Research Institute, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Government Dental College & Research Institute, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28413591</idno><idno type="pmc">5390121</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390121</idno><idno type="RBID">PMC:5390121</idno><idno type="doi">10.15171/joddd.2017.004</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">003110</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003110</idno><idno type="wicri:Area/Pmc/Curation">003110</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003110</idno><idno type="wicri:Area/Pmc/Checkpoint">000287</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000287</idno><idno type="wicri:Area/Ncbi/Merge">006F40</idno><idno type="wicri:Area/Ncbi/Curation">006F40</idno><idno type="wicri:Area/Ncbi/Checkpoint">006F40</idno><idno type="wicri:doubleKey">2008-210X:2017:S Martande S:comparative:evaluation:of</idno><idno type="wicri:Area/Main/Merge">000311</idno><idno type="wicri:Area/Main/Curation">000311</idno><idno type="wicri:Area/Main/Exploration">000311</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial</title><author><name sortKey="S Martande, Santosh" sort="S Martande, Santosh" uniqKey="S Martande S" first="Santosh" last="S. Martande">Santosh S. Martande</name><affiliation wicri:level="1"><nlm:aff id="A01">Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune</wicri:regionArea><wicri:noRegion>Pune</wicri:noRegion></affiliation></author><author><name sortKey="Kumari, Minal" sort="Kumari, Minal" uniqKey="Kumari M" first="Minal" last="Kumari">Minal Kumari</name><affiliation wicri:level="1"><nlm:aff id="A02">Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Pradeep, A R" sort="Pradeep, A R" uniqKey="Pradeep A" first="A. R." last="Pradeep">A. R. Pradeep</name><affiliation wicri:level="1"><nlm:aff id="A03">Department of Periodontics, Government Dental College & Research Institute, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Government Dental College & Research Institute, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Pal Singh, Sonender" sort="Pal Singh, Sonender" uniqKey="Pal Singh S" first="Sonender" last="Pal Singh">Sonender Pal Singh</name><affiliation wicri:level="1"><nlm:aff id="A03">Department of Periodontics, Government Dental College & Research Institute, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Government Dental College & Research Institute, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Kumar Suke, Deepak" sort="Kumar Suke, Deepak" uniqKey="Kumar Suke D" first="Deepak" last="Kumar Suke">Deepak Kumar Suke</name><affiliation wicri:level="1"><nlm:aff id="A03">Department of Periodontics, Government Dental College & Research Institute, Bangalore, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Government Dental College & Research Institute, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Dental Research, Dental Clinics, Dental Prospects</title><idno type="ISSN">2008-210X</idno><idno type="eISSN">2008-2118</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold><italic>Background.</italic></bold> Statins are the recently evolved agents that aid in periodontal regeneration and ultimately in attaining periodontal health. Atorvastatin (ATV) and Simvastatin (SMV) are specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The current study was conducted to compare the effectiveness of 1.2% ATV and 1.2% SMV, in addition to scaling and root planing (SRP), in the treatment of intrabony defects in subjects with chronic periodontitis.</p><p><bold><italic>Methods.</italic></bold> Ninety-six individuals were categorized into three treatment groups: SRP plus 1.2% ATV, SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters of full-mouth plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), and relative attachment level (RAL) were recorded at baseline before SRP and at 3, 6 and 9 months. Bone fill was assessed using percentage radiographic defect depth reduction at baseline, 6 months and 9 months.</p><p><italic><bold>Results.</bold></italic> Both ATV and SMV showed significant PD reduction and RAL gain than placebo. ATV group showed greater mean PD reduction and mean RAL gain as compared to SMV group at 3, 6 and 9 months. Furthermore, ATV group sites exhibited a significantly greater percentage of radiographic defect depth reduction (33.23 ± 3.11%; 34.84 ± 3.07%) as compared to SMV (30.39 ± 3.36%; 32.15 ± 3.37%) at 6 and 9 months.</p><p><italic><bold>Conclusion.</bold></italic> ATV resulted in greater improvements in clinical parameters with higher percentage of radiographic defect depth reduction as compared to SMV in the treatment of intrabony defects in CP subjects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Seymour, Gj" uniqKey="Seymour G">GJ Seymour</name></author><author><name sortKey="Gemmell, E" uniqKey="Gemmell E">E Gemmell</name></author><author><name sortKey="Reinhardt, Ra" uniqKey="Reinhardt R">RA Reinhardt</name></author><author><name sortKey="Eastcott, J" uniqKey="Eastcott J">J Eastcott</name></author><author><name sortKey="Taubman, Ma" uniqKey="Taubman M">MA 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Martande">Santosh S. Martande</name></noRegion><name sortKey="Kumar Suke, Deepak" sort="Kumar Suke, Deepak" uniqKey="Kumar Suke D" first="Deepak" last="Kumar Suke">Deepak Kumar Suke</name><name sortKey="Kumari, Minal" sort="Kumari, Minal" uniqKey="Kumari M" first="Minal" last="Kumari">Minal Kumari</name><name sortKey="Pal Singh, Sonender" sort="Pal Singh, Sonender" uniqKey="Pal Singh S" first="Sonender" last="Pal Singh">Sonender Pal Singh</name><name sortKey="Pradeep, A R" sort="Pradeep, A R" uniqKey="Pradeep A" first="A. R." last="Pradeep">A. R. Pradeep</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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